Description
Current research suggests the following potential benefits:
Cognitive and neurological effects
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- Neuroprotection and nerve regeneration: Semax has been studied for its ability to promote the survival and regeneration of neurons. Studies on N-acetyl semax show it may improve recovery and support motor performance after nerve damage.
- Enhanced brain function: Research suggests that N-acetyl semax may increase levels of brain-derived neurotrophic factor (BDNF). BDNF is crucial for the growth and survival of brain cells, as well as for brain plasticity.
- Improved memory and learning: Studies indicate that Semax and its analogs can improve attention, memory, and concentration.
- Attention-deficit/hyperactivity disorder (ADHD): Research suggests Semax may have potential therapeutic value for ADHD due to its effect on dopamine release and BDNF synthesis.
- Stroke and ischemia: In Russia, Semax is used to treat ischemic stroke and has been shown to protect neurons during hypoxic conditions.
Mood and stress
- Mood enhancement: By modulating serotonin and dopamine systems in the brain, N-acetyl semax may produce mood-enhancing and antidepressant-like effects.
- Stress management: The peptide has been shown to have anxiolytic (anxiety-reducing) properties and can help the brain adapt to chronic stress.
Comparison with Semax
The modifications in N-acetyl semax amidate alter the peptide’s properties compared to the original Semax:
- Increased stability: The N-acetylation modification may prevent the peptide’s degradation and prolong its effects in the body.
- Increased potency: This modification is thought to enhance the compound’s potency.
- Altered properties: N-terminal acetylation can modify the peptide’s ability to interact with ions, such as copper (Cu(II)), which may affect its cellular protection mechanisms